This booklet, developed in collaboration with WFP, is the second in The Partnering Initiative’s Navigator series. It has been designed as a practical guide to help users navigate the challenges of dealing with different organisational cultures when working in cross-sector partnerships. Differences in organisational and professional cultures are a common source of misunderstanding in international collaboration: they can reduce the efficiency and the impact of cross-sector partnerships and can generate risk. The Navigator outlines a number of key issues for consideration and proposes some achievable actions that can be taken both to make it easier to deal with different cultures and to make your own organisational culture more partnership-friendly.